Abstract
Hypervalent iodine (HVI) reagents are versatile reagents that have a wide variety of uses in organic synthesis. However, these reagents are quite polar and are often limited to be used in polar solvents. Disclosed here are four new reagents, three of which are liquids that are miscible in both hexanes and acetonitrile. The partition coefficients of these liquid reagents are measured between hexanes and acetonitrile. Liquid reagents have
advantages in applications using flow reactors and solventless transformations. Synthesis of these new reagents by adapting previously disclosed syntheses as well as developing new methods, are disclosed below. During this study, we developed a method to remove an overlooked impurity in commercially available phenyliodine diacetate.