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Redefining the structure-activity relationships of 2,6-methano-3- benzazocines. 4. Opioid receptor binding properties of 8-[n-(4′-phenyl)- phenethyl)carboxamido] analogues of cyclazocine and ethylketocycalzocine
Journal article   Peer reviewed

Redefining the structure-activity relationships of 2,6-methano-3- benzazocines. 4. Opioid receptor binding properties of 8-[n-(4′-phenyl)- phenethyl)carboxamido] analogues of cyclazocine and ethylketocycalzocine

M.P. Wentland, M. VanAlstine, R. Kucejko, R. Lou, D.J. Cohen, A.L. Parkhill and J.M. Bidlack
Journal of medicinal chemistry, Vol.49(18), pp.5635-5639
2006
DOI: https://doi.org/10.1021/jm060278n

Abstract

Opioids--Receptors Synthesis Phenols
The synthesis and evaluation of a series of aryl-containing N-monosubstituted analogues of the lead compound 8-carboxamidocyclazocine were performed to probe a putative hydrophobic binding pocket of opioid receptors. High binding affinity to μ, κ, and δ opioid receptors was observed for the 8-[N-(4‘-phenyl)-phenethyl)carboxamido] analogue.
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