Sign in
Lewis Acid Catalyzed Borotropic Shifts in the Design of Diastereo- and Enantioselective γ-Additions of Allylboron Moieties to Aldimines
Journal article

Lewis Acid Catalyzed Borotropic Shifts in the Design of Diastereo- and Enantioselective γ-Additions of Allylboron Moieties to Aldimines

F.W. Van Der Mei, H. Miyamoto, D.L. Silverio and A.H. Hoveyda
Angewandte Chemie International Edition in English, Vol.55(15), pp.4701-4706
2016

Abstract

Boron Enantioselective catalysis Enantioselective catalysis
Catalytic allylboron additions to aldimines are presented for which small amounts of Zn(OMe)2 serve as the co-catalyst to accelerate allyl exchange and 1,3-borotropic shift processes. Low-yielding and moderately α- and diastereoselective reactions are thus turned into highly efficient γ-, diastereo-, and enantioselective transformations that exhibit considerable scope.
url
Version of RecordView

Metrics

1 Record Views

Details