Brain-based classification of youth with anxiety disorders: transdiagnostic examinations within the ENIGMA-Anxiety database using machine learning

Willem B. Bruin; Paul Zhutovsky; Guido A. van Wingen; Janna Marie Bas-Hoogendam; Nynke A. Groenewold; Kevin Hilbert; Anderson M. Winkler; Andre Zugman; Federica Agosta; Fredrik Åhs; Carmen Andreescu; Chase Antonacci; Takeshi Asami; Michal Assaf; Jacques P. Barber; Jochen Bauer; Shreya Y. Bavdekar; Katja Beesdo-Baum; Francesco Benedetti; Rachel Bernstein; Johannes Björkstrand; Robert J. Blair; Karina S. Blair; Laura Blanco-Hinojo; Joscha Böhnlein; Paolo Brambilla; Rodrigo A. Bressan; Fabian Breuer; Marta Cano; Elisa Canu; Elise M. Cardinale; Narcís Cardoner; Camilla Cividini; Henk Cremers; Udo Dannlowski; Gretchen J. Diefenbach; Katharina Domschke; Alexander G. G. Doruyter; Thomas Dresler; Angelika Erhardt; Massimo Filippi; Gregory A. Fonzo; Gabrielle F. Freitag; Tomas Furmark; Tian Ge; Andrew J. Gerber; Savannah N. Gosnell; Hans J. Grabe; Dominik Grotegerd; Ruben C. Gur; Raquel E. Gur; Alfons O. Hamm; Laura K. M. Han; Jennifer C. Harper; Anita Harrewijn; Alexandre Heeren; David Hofmann; Andrea P. Jackowski; Neda Jahanshad; Laura Jett; Antonia N. Kaczkurkin; Parmis Khosravi; Ellen N. Kingsley; Tilo Kircher; Milutin Kostic; Bart Larsen; Sang-Hyuk Lee; Elisabeth J. Leehr; Ellen Leibenluft; Christine Lochner; Su Lui; Eleonora Maggioni; Gisele G. Manfro; Kristoffer N. T. Månsson; Claire E. Marino; Frances Meeten; Barbara Milrod; Ana Munjiza Jovanovic; Benson Mwangi; Michael J. Myers; Susanne Neufang; Jared A. Nielsen; Patricia A. Ohrmann; Cristina Ottaviani; Martin P. Paulus; Michael T. Perino; K. Luan Phan; Sara Poletti; Daniel Porta-Casteràs; Jesus Pujol; Andrea Reinecke; Grace V. Ringlein; Pavel Rjabtsenkov; Karin Roelofs; Ramiro Salas; Giovanni A. Salum; Theodore D. Satterthwaite; Elisabeth Schrammen; Lisa Sindermann; Jordan W. Smoller; Jair C. Soares; Rudolf Stark; Frederike Stein; Thomas Straube; Benjamin Straube; Jeffrey R. Strawn; Benjamin Suarez-Jimenez; Chad M. Sylvester; Ardesheer Talati; Sophia I. Thomopoulos; Raşit Tükel; Helena van Nieuwenhuizen; Kathryn Werwath; Katharina Wittfeld; Barry Wright; Mon-Ju Wu; Yunbo Yang; Anna Zilverstand; Peter Zwanzger; Jennifer U. Blackford; Suzanne N. Avery; Jacqueline A. Clauss; Ulrike Lueken; Paul M. Thompson; Daniel S. Pine; Dan J. Stein; Nic J. A. van der Wee; Dick J. Veltman; Moji Aghajani

doi:10.1038/s44220-023-00173-2

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Brain-based classification of youth with anxiety disorders: transdiagnostic examinations within the ENIGMA-Anxiety database using machine learning

Journal article

Peer reviewed

Brain-based classification of youth with anxiety disorders: transdiagnostic examinations within the ENIGMA-Anxiety database using machine learning

Willem B. Bruin, Paul Zhutovsky, Guido A. van Wingen, Janna Marie Bas-Hoogendam, Nynke A. Groenewold, Kevin Hilbert, Anderson M. Winkler, Andre Zugman, Federica Agosta, Fredrik Åhs, …

Nature mental health, Vol.2(1), pp.104-118

01/10/2024

DOI: https://doi.org/10.1038/s44220-023-00173-2

Abstract

Anxiety

Classification

Big data

Machine Learning

Neuroanatomical findings on youth anxiety disorders are notoriously difficult to replicate, small in effect size and have limited clinical relevance. These concerns have prompted a paradigm shift toward highly powered (that is, big data) individual-level inferences, which are data driven, transdiagnostic and neurobiologically informed. Here we built and validated supervised neuroanatomical machine learning models for individual-level inferences, using a case–control design and the largest known neuroimaging database on youth anxiety disorders: the ENIGMA-Anxiety Consortium (N = 3,343; age = 10–25 years; global sites = 32). Modest, yet robust, brain-based classifications were achieved for specific anxiety disorders (panic disorder), but also transdiagnostically for all anxiety disorders when patients were subgrouped according to their sex, medication status and symptom severity (area under the receiver operating characteristic curve, 0.59–0.63). Classifications were driven by neuroanatomical features (cortical thickness, cortical surface area and subcortical volumes) in fronto-striato-limbic and temporoparietal regions. This benchmark study within a large, heterogeneous and multisite sample of youth with anxiety disorders reveals that only modest classification performances can be realistically achieved with machine learning using neuroanatomical data.

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Title: Brain-based classification of youth with anxiety disorders: transdiagnostic examinations within the ENIGMA-Anxiety database using machine learning
Creators: Willem B. Bruin - Amsterdam University Medical Centers
Paul Zhutovsky - Amsterdam University Medical Centers
Guido A. van Wingen - Amsterdam University Medical Centers
Janna Marie Bas-Hoogendam - Leiden University
Nynke A. Groenewold - Red Cross War Memorial Children's Hospital
Kevin Hilbert - Humboldt-Universität zu Berlin
Anderson M. Winkler - The University of Texas Rio Grande Valley
Andre Zugman - National Institute of Mental Health
Federica Agosta - Vita-Salute San Raffaele University
Fredrik Åhs - Mid Sweden University
Carmen Andreescu - University of Pittsburgh
Chase Antonacci - National Institute of Mental Health
Takeshi Asami - Yokohama City University
Michal Assaf - Institute for Community Living
Jacques P. Barber - Adelphi University
Jochen Bauer - University of Münster
Shreya Y. Bavdekar - University of Rochester
Katja Beesdo-Baum
Francesco Benedetti - Vita-Salute San Raffaele University
Rachel Bernstein - National Institute of Mental Health
Johannes Björkstrand - Lund University
Robert J. Blair - Mental Health Services
Karina S. Blair - Boys Town
Laura Blanco-Hinojo
Joscha Böhnlein - University of Münster
Paolo Brambilla - University of Milan
Rodrigo A. Bressan - Universidade Federal de São Paulo
Fabian Breuer - University of Münster
Marta Cano - Hospital de Sant Pau
Elisa Canu - Vita-Salute San Raffaele University
Elise M. Cardinale - University of America
Narcís Cardoner - Hospital de Sant Pau
Camilla Cividini - Vita-Salute San Raffaele University
Henk Cremers - University of Amsterdam
Udo Dannlowski - University of Münster
Gretchen J. Diefenbach - Hartford Hospital
Katharina Domschke - University of Freiburg
Alexander G. G. Doruyter
Thomas Dresler
Angelika Erhardt - Max Planck Institute of Psychiatry
Massimo Filippi - Vita-Salute San Raffaele University
Gregory A. Fonzo - The University of Texas at Austin
Gabrielle F. Freitag - Florida Department of Children and Families
Tomas Furmark - Uppsala University
Tian Ge - Massachusetts General Hospital
Andrew J. Gerber - Columbia University Irving Medical Center
Savannah N. Gosnell - Baylor College of Medicine
Hans J. Grabe - Greifswald University Hospital
Dominik Grotegerd - University of Münster
Ruben C. Gur - University of Pennsylvania
Raquel E. Gur - University of Pennsylvania
Alfons O. Hamm - University of Greifswald
Laura K. M. Han - University of Melbourne
Jennifer C. Harper - Washington University in St. Louis
Anita Harrewijn - National Institute of Mental Health
Alexandre Heeren - UCLouvain
David Hofmann - University of Münster
Andrea P. Jackowski - Universidade Federal de São Paulo
Neda Jahanshad - University of Southern California
Laura Jett - National Institute of Mental Health
Antonia N. Kaczkurkin - Vanderbilt University
Parmis Khosravi - National Institute of Mental Health
Ellen N. Kingsley - Leeds and York Partnership NHS Foundation Trust
Tilo Kircher - Philipps University of Marburg
Milutin Kostic - Institute of Mental Health
Bart Larsen - University of Pennsylvania
Sang-Hyuk Lee
Elisabeth J. Leehr - University of Münster
Ellen Leibenluft - National Institute of Mental Health
Christine Lochner - Stellenbosch University
Su Lui - Sichuan University
Eleonora Maggioni - Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
Gisele G. Manfro - Universidade Federal do Rio Grande do Sul
Kristoffer N. T. Månsson
Claire E. Marino - University of Rochester
Frances Meeten - University of Sussex
Barbara Milrod - Albert Einstein College of Medicine
Ana Munjiza Jovanovic - Institute of Mental Health
Benson Mwangi - The University of Texas Health Science Center at Houston
Michael J. Myers - Washington University in St. Louis
Susanne Neufang - Heinrich Heine University Düsseldorf
Jared A. Nielsen - Harvard University
Patricia A. Ohrmann - University of Münster
Cristina Ottaviani - Sapienza University of Rome
Martin P. Paulus - Laureate Institute for Brain Research
Michael T. Perino - Washington University in St. Louis
K. Luan Phan - The Ohio State University
Sara Poletti - Vita-Salute San Raffaele University
Daniel Porta-Casteràs - Universitat Autònoma de Barcelona
Jesus Pujol - Instituto de Salud Carlos III
Andrea Reinecke - University of Oxford
Grace V. Ringlein - National Institute of Mental Health
Pavel Rjabtsenkov - University of Rochester
Karin Roelofs - Radboud University Nijmegen
Ramiro Salas - Baylor College of Medicine
Giovanni A. Salum
Theodore D. Satterthwaite - University of Pennsylvania
Elisabeth Schrammen - University of Münster
Lisa Sindermann - University Hospital Bonn
Jordan W. Smoller - Massachusetts General Hospital
Jair C. Soares - The University of Texas Health Science Center at Houston
Rudolf Stark - Universitätsklinikum Gießen und Marburg
Frederike Stein - Philipps University of Marburg
Thomas Straube - University of Münster
Benjamin Straube - Philipps University of Marburg
Jeffrey R. Strawn - University of Cincinnati
Benjamin Suarez-Jimenez
Chad M. Sylvester - Washington University in St. Louis
Ardesheer Talati - Columbia University Irving Medical Center
Sophia I. Thomopoulos - University of Southern California
Raşit Tükel - Istanbul University
Helena van Nieuwenhuizen - Stony Brook University
Kathryn Werwath - National Institute of Mental Health
Katharina Wittfeld - Greifswald University Hospital
Barry Wright - Hull York Medical School
Mon-Ju Wu - The University of Texas Health Science Center at Houston
Yunbo Yang - Philipps University of Marburg
Anna Zilverstand - University of Minnesota
Peter Zwanzger - LMU Klinikum
Jennifer U. Blackford - University of Nebraska Medical Center
Suzanne N. Avery - Vanderbilt University Medical Center
Jacqueline A. Clauss - Massachusetts General Hospital
Ulrike Lueken
Paul M. Thompson - University of Southern California
Daniel S. Pine - National Institute of Mental Health
Dan J. Stein - University of Cape Town
Nic J. A. van der Wee - Leiden University Medical Center
Dick J. Veltman - Vrije Universiteit Amsterdam
Moji Aghajani - Leiden University
Publication Details: Nature mental health, Vol.2(1), pp.104-118
Academic Unit: Gordon F. Derner School of Psychology; Adelphi University
Language: English
Resource Type: Journal article
DOI: https://doi.org/10.1038/s44220-023-00173-2
Record Identifier: 991004380895306266